276 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
By combining live-cell imaging, traction force microscopy, and Hidden Markov Modeling, this study reveals that fibroblast migration is organized into discrete mechanical states characterized by specific couplings of force generation, cell shape, and motion, which persist even when cytoskeletal organization is disrupted.
This study reveals that liver sinusoidal endothelial cells integrate diverse inflammatory, metabolic, and oxidative stress signals via MAPK-dependent pathways to upregulate BMP6, which, in concert with hepatocyte secreted factors, drives hepcidin induction and subsequent hypoferremia to maintain iron homeostasis.
This study demonstrates that MARK4 localizes to stress granules via its spacer domain and kinase activity to enhance their formation by suppressing TIA1 dimerization, thereby synergistically promoting tau accumulation and toxicity in models of Alzheimer's disease.
This study reveals that glycogen synthase kinase 3 (GSK3) regulates septin 9 (SEPT9) distribution between actin and microtubule cytoskeletons through a phosphorylation-dependent switch, thereby controlling neuronal polarization and linking cytoskeletal dynamics to broader cellular signaling pathways.
This study introduces a novel therapeutic strategy that utilizes RNA-guided CRISPR-Cas12a2 to selectively eliminate cancer cells harboring TP53 mutations by detecting tumor-specific transcripts to trigger trans-chromatin cleavage and cell death, thereby offering a solution for targeting previously undruggable mutations.
This study demonstrates that skeletal muscle fibers adapt to a reduced number of myonuclei by actively optimizing their spatial distribution, resulting in increased regularity and uniformity along the fiber axis and surface to maintain efficient intracellular organization.
This study utilizes structural analysis and functional assays to reveal that HIF-2α's subcellular localization is governed by specific domain interactions independent of canonical dimerization, while demonstrating that its oncogenic potential relies on non-canonical cytoplasmic mechanisms and protein interactions rather than its traditional transcriptional activation domains.
This study demonstrates that genetic depletion of septins in zebrafish unexpectedly enhances macrophage-mediated protection against mycobacterial infection by driving the overproduction of myeloid-biased haematopoietic stem and progenitor cells, thereby establishing a critical role for septins in regulating haematopoiesis and offering new insights into blood disorders like acute myeloid leukaemia.
This study demonstrates that in cultured human myoblasts, intrinsic IL-6 expression acts as a negative feedback regulator that dampens extrinsic IL-6-induced JAK/STAT signaling while simultaneously functioning synergistically with it to promote glucose and oleic acid oxidation.
This study demonstrates that a lightweight, interpretable framework using rotation-invariant Local Ternary Pattern descriptors on endogenous autofluorescence intensity patterns can accurately and non-destructively distinguish human pancreatic - and -cells based on their distinct lipofuscin-rich granule organization, eliminating the need for destructive labeling or specialized imaging hardware.